YAP5SA, an Introduction

Continuing our video series, Dr. Martin explains in this five-minute clip how our lab leverages cutting-edge techniques to understand the complexities of heart failure. Using the YAP5SA transgene in mice, our team is investigating the role of YAP (Yes-associated protein) activation in promoting cardiac regeneration. YAP5SA is a modified form of YAP, designed to remain active and bypass inhibitory phosphorylation, making it a powerful tool for studying cardiac regeneration.

By deciphering how gene regulation and cell-cell interactions can foster tissue regeneration, our work on YAP5SA will pave the way for new heart failure therapeutics. Stay tuned for more breakthroughs as we continue to combat one of the leading causes of death worldwide.